For IL-6 we failed to reveal a clear association pattern with renal failure as in the case of sTNF-R1 and hsCRP in either sex (Table 2, 3); here we estimated similar AUCs as in the case of hsCRP for both sexes, which is also true for the sensitivity and specificity at the optimal cut offs (Table 2, 3). The gene discussed is IL6; the disease is Renal insufficiency.