CD22 and Hodgkins lymphoma: It was also suggested that the heterosynkaryons of Hodgkin lymphoma with their Hodgkin Reed-Sternberg (HRS) cells retained their B-cell origin [37], confirming other evidence for a B-cell origin of this neoplasm [67], and again corroborated herein by gene probe analysis disclosing B-cell genes (CD20, CD22) in these specimens.