[34] The association was mainly in NOD2 (Figure S1A, upper, in File S1); a conditional analysis demonstrated that all of the association observed at this locus in Puerto Ricans was explained by the European SNPs (data not shown). None of the three European IBD susceptibility haplotypes were present in HGDP Africans, and only one was observed in HGDP Americans (Table 3). The local continental ancestry at NOD2 in Puerto Ricans was mostly European with very little African ancestry (Figure S1A, lower, in File S1). The gene discussed is NOD2; the disease is inflammatory bowel disease.