Putta et al. treated STZ-induced diabetic C57 mice with locked nucleic acid (LNA) modified anti-miR-192 and observed significantly increased ECM repressor ZEB1/2 and decreased expression of TGF-β, collagen, and fibronectin (FN) in diabetic kidney, as well as attenuated proteinuria [26], thus indicating the possibility of the approach of LNA-anti-miR-192 to the treatment of DN. The gene discussed is ZEB1; the disease is liver dysplastic nodule.