Fiorentino et al. found that, in a mice model of type 1 diabetes, SV40 MES 13 mouse mesangial cells, as well as human kidney biopsies from patients of DN, miR-21 were significantly upregulated, which led to downregulation of tissue inhibitors of metalloproteinase 3 (TIMP3) [35]. This evidence concerns the gene TIMP3 and liver dysplastic nodule.