Glutamate, proteases, leukotrienes, IL-1β, IL-6, TNF-α, VEGF, lymphotoxin MMPs, and ROS have all been linked to diabetic retinopathy and a role for MIP-1, IL-1, and IL-3 in angiogenesis has been established in ischemic mouse models [56, 85, 98–102]. The gene discussed is VEGFA; the disease is diabetic retinopathy.