During the screening of a TCM extract library (400 biotas) on GLUT4 translocation in myotubes, we found a methanolic extract of the traditional Chinese medicine, Berberis julianae Schneid., which has long been used for the treatment of infection and hypertension [12], displayed promising positive activity on GLUT4 translocation. Here, SLC2A4 is linked to Hypertension.