BSACI recommendations [36] for amino acid formulas include the following: infants and children with (1) severe CMA (failure to thrive and abundant blood in stools), (2) multiple food allergies, (3) allergic symptoms or severe atopic eczema when exclusively breastfed, (4) severe forms of non-IgE-mediated CMA, such as eosinophilic esophagitis, enteropathies, and food protein-induced enterocolitis syndrome, (5) growth faltering, and/or (6) infants at nutritional risk with reactions to or refusal to ingest appropriate amounts of extensively hydrolyzed formula. Here, IGHE is linked to atopic eczema.