NR1H4 and nicotine dependence: Other FXR-active drugs include two synthetic steroids (ethinylestradiol and ethylestrenol), an anticoagulant pyrimidine (dipyridamole), an antinematodal isoquinoline (emetine), an anti-infective aminoacridine (ethacridine lactate), an anti-gout alkaloid (colchicine), and a pyrazole drug to treat nicotine addiction (surinabant).