ADCYAP1 and ischemia: Applying the DNA microarray (4x44K whole genome transcriptomic profiling) and two-dimensional gel electrophoresis (2-DGE) linked with mass spectrometry approaches [15,16,17], our previous research revealed the first ischemia-related transcriptome and proteome of the mouse brain, laying a strong foundation for studies designed to elucidate the mechanisms regulating ischemia and to explore the neuroprotective effects of agents such as target neuropeptides, including PACAP38 [12,13,14].