MAPT and Mental deterioration: Additional concerns are raised by findings showing that, a) tau pathology occurs in the absence of Aβ deposits and in the absence of microglial activation [89–91]; b) administration of anti-inflammatory drugs does not slow or reverse tau pathology or cognitive decline [92–94]; c) tau pathology is not initiated or exacerbated by presence of severe neuroinflammation [95]; d) tau pathology does not occur in transgenic animals overexpressing amyloid precursor protein despite extensive Aβ deposition and associated microglial activation [96–98].