To investigate if RANKL gene expression in MM cells could be associated with Notch pathway activation in MM patients, we evaluated RANKL and Notch target HES6 gene expression profiles from a proprietary data set (GEO accession number: GSE 39925) of highly purified PC samples from 55 newly-diagnosed MM patients [31] profiled on Affymetrix Gene 1.0 ST array. Here, HES6 is linked to Miyoshi myopathy.