Our analysis of 108 ALGGs encompassing astrocytic, mixed and oligodendroglial lineage tumors revealed that TP53 mutations were most frequent in astrocytic and mixed lineage tumors but were rarely present in oligodendroglial tumors and when present were only seen in anaplastic oligodendrogliomas, consistent with previous studies [19]. The gene discussed is TP53; the disease is anaplastic oligodendroglioma.