Of the seven AA3 tumors, three contained EGFR amplification with monosomy 10 or CDKN2A/B deletion, a pattern more typical of GBM than ALGG suggesting that these tumors may in fact be more clinically aggressive than typical AA3s or under-sampled with respect to the overall features of the tumor (Figure 4). The gene discussed is CDKN2A; the disease is glioblastoma.