Our meta-analysis results indicated that IL-10 -819C/T (C versus T, OR = 1.28, 95% CI = 1.08–1.50, P = 0.003) and -592C/A (C versus A, OR = 1.28, 95% CI = 1.03–1.59, P = 0.03) polymorphisms were associated with preeclampsia. This evidence concerns the gene IL10 and preeclampsia.