Further studies demonstrated that bufalin, one compound in Chansu, induced apoptosis of gastric cancer cells by inhibition of AKT signaling pathway [37] and inhibiting proliferation of hepatocellular carcinoma cells through inhibiting AKT/GSK3β/β-catenin/E-cadherin signaling pathway [38]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.