APC and intestinal neoplasm: The human CRC mucosa-associated E. coli strain 11G5 promoted intestinal neoplastic changes when introduced in Apcmin/+ mice, which carry a mutation in one allele of the tumor suppressor gene adenomatous polyposis coli (Apc) and are genetically predisposed to developing intestinal tumors (Bonnet et al., 2014) (Table 1).