TNFRSF18 and systemic lupus erythematosus: In CD4+CD25low/-GITR+ cells from SLE patients, the mRNA expression of CTLA-4, IL-10, and TGF-β was similar to those seen in CD4+CD25low/-GITR+ cells from HC, and the mRNA expression of FoxP3 was even higher (Figure 4A through D).