CD4 and systemic lupus erythematosus: Comparison between Figure 8D and C suggests that SLE CD4+CD25low/-GITR+ cells over HC effectors had a much higher regulatory activity than did HC CD4+CD25low/-GITR+ cells over SLE effectors (P <0.01), and comparison between Figure 8A and C suggests that HC CD4+CD25low/-GITR+ cells over HC effectors had a higher regulatory activity than over SLE effectors, in accordance with the partial resistance to suppression of SLE effectors [5,6].