The mean inhibition by CD4+CD25low/-GITR+ cells from HC was equal to 16.8% ±12.9% and the mean inhibition by CD4+CD25low/-GITR+ cells from SLE patients was equal to 27.2% ±14.5%, confirming that the regulatory activity of cells from SLE was higher than that from HC, when the inhibition of the same effectors was evaluated. This evidence concerns the gene TNFRSF18 and systemic lupus erythematosus.