SLA or SLX determinant synthesized on surface of cancer cells and E-selectin expressed on endothelial cells induced by inflammatory stimulus such as TNF-α, IL-1α or IL-1β are required for hematogenous metastasis because the adhesion of malignant cells to the vascular endothelium is an important step for extravasation into target tissues of a new organ[4–6]. The gene discussed is SELE; the disease is cancer.