Among numerous novel targets involved in essential trafficking pathways, we discovered N-myristoylation of LAMTOR1 (ref. 44)44, which anchors the scaffolding complex of the mTORC1 and MAPK pathways, and Battenin/CLN3 (ref. 45)45, mutations of which can result in Batten disease, a fatal inherited neurodegenerative disorder. This evidence concerns the gene LAMTOR1 and juvenile neuronal ceroid lipofuscinosis.