In addition, at day 6 post infection, there was a modest but significant increase in viral load in the spleen and liver in mice receiving poly(I∶C)-pretreated P14 CD8 T cells (4.2±0.07 log pfu in the spleen, 4.2±0.08 log pfu in the liver) compared to mice receiving HBSS-pretreated P14 cells (3.8±0.12 log pfu in the spleen, 3.8±0.08 log pfu in the liver) (3 independent experiments combined for n = 14–15, p = 0.0197 (spleen) and p = 0.0074 (liver)). This evidence concerns the gene CD8A and infection.