However, when adult Fibulin-4+/R lungs were triggered by LPS administration, which mimics bacterial infection in mice by initiating the infiltration of inflammatory cells into the pulmonary alveoli similar to patients with COPD exacerbation [26], [27], flow cytometric analyses of BAL samples and pulmonary cell suspensions showed an increased and prolonged inflammatory response as compared to Fibulin-4+/+ mice. The gene discussed is EFEMP2; the disease is chronic obstructive pulmonary disease.