Next, gene expression data from the comparison between Fibulin-4+/+ and Fibulin-4R/R lungs (374 genes) were compared to this list of COPD-related genes derived from IPA, where we found an overlap of 6 genes: PDE3B (1.28 ↑), HCK (1.55 ↑), PRF1 (1.47 ↑), SERPINA1 (1.38 ↓), FGFR3 (1.28 ↓), and EFEMP2 (i.e. Fibulin-4, 3.57 ↓). This evidence concerns the gene SERPINA1 and chronic obstructive pulmonary disease.