Inactivation of Abcd2 alone has no significant effect on the levels of saturated VLCFA in most murine tissues including brain, spinal cord and sciatic nerve, which are affected by the pathology in X-ALD [31], which is also the case in our Abcd2−/− mouse strain (Forss-Petter, unpublished observation). The gene discussed is ABCD2; the disease is X-linked adrenoleukodystrophy.