Other significant predicted targets include transforming growth factors like TGFB2 and transforming growth factor beta receptor, TGFBR3. The three different isoforms of TGF-beta have been shown to play a significant role in myocardial infarction and in the regulation of hypertrophic cardiac remodeling [53]. The gene discussed is TGFB2; the disease is myocardial infarction.