Indeed, these molecules have been shown to be involved in apoptotic process in various cancer cells.34,38, 39, 40 To demonstrate DDIT4, PARP3 and EP300 were targets for miR-630, the full-length 3'-UTRs and their mutants (Supplementary Figure S7) were inserted downstream of the pMiR-Reporter vector to generate wild-type and mutant reporters, respectively. The gene discussed is EP300; the disease is cancer.