A recent study showed that regulation of the DICER1 promoter by ATM-phosphorylated delta-DNp63a was implicated in CIS-induced alteration in microRNAome (including miR-630).34 We reported recently that CIS-induced miR-630 was attributed to the promotion of pri-miR-630 processing by E2F1-regulated DROSHA.51 However, activation of the miR-630 gene by DNA damage is unknown. Here, E2F1 is linked to in situ carcinoma.