Next, we performed individual and combined silencing of three molecules in A549 by specific siRNA oligonucleotides41,42 (also see http: //www.pnas.org/cgi/content/short/1016574108) to examine the effects of targeting DDIT4, PARP3 and EP300 by miR-630 on CIS-induced apoptosis. This evidence concerns the gene EP300 and in situ carcinoma.