IGF1R and in situ carcinoma: MicroRNA-630 (MiR-630) is induced by cisplatin (CIS) and 3-Cl-AHPC (an adamantyl retinoid-related molecule), and it causes apoptosis in certain types of cancer cells by targeting different molecules such as BCL2, BCL2L2 and IGF-1R.34,35 Moreover, miR-630 exerts cytoprotective effects in CIS-administered A549 cells, but rather behaves as a specific cell death modulator in oxaliplatin-exposed A549 and CIS-exposed H1650, H1975 and HCC827 cells.36 These observations indicate that the role of miR-630 in regulating apoptosis is not fully understood.