IGF1R and cancer: Depletion of CDC7 induces apoptosis in cancer cells.15,16 MiR-630 may target BCL2, BCL2L2 and IGF-1R to induce apoptosis under genotoxic stresses.34,35 As an miRNA may have multiple targets,14,37 we speculated that miR-630-induced inhibitory proliferation and, perhaps, apoptosis might be linked to CDC7.