CISH and cancer: Depletion of CDC7 in cancer cells impairs progression through the S phase.1,11,15,16 Transfection of pre-miR-630 arrests A549 at G0/G1 by p27Kip1 induction upon CIS exposure.36 Similarly, we found that miR-630 transfection arrested A549 at the G1 phase(Figure 6e), and CIS exposure induced G1 arrest (Figures 6a and b), followed by miR-630 induction (Figure 6c).