CDC7 and in situ carcinoma: Surprisingly, we could not detect apoptosis in miR-630 transfected cells (Figure 5a and Supplementary Figure S6), indicating that overexpression of miR-630 and depletion of CDC7 by RNA interference (RNAi) (or downregulation of CDC7 by CIS) do not have equal effect on apoptosis, probably because of the multiple target effects of miR-630.