Fucoidan (sulfated polysaccharide derived from brown algae) Decreased the viable number of 4T1 cells; induced apoptosis; down-regulated VEGF expression In colon cancer reduced in viable cell numbers and induced apoptosis of human lung carcinoma A549 cells as well as colon cancer HT-29 and HCT116 cells. The gene discussed is VEGFA; the disease is malignant colon neoplasm.