Furthermore, additional studies suggest that EGCG can also decrease the phosphorylated forms of ERK and mitogen-activated protein (MEK1) through its oxidative stress inhibition of the association between Raf-1 and MEK1/ERK kinase1, leading to suppression of proliferation of the HT29 human colon cancer cell line [62]. The gene discussed is MAP2K1; the disease is colonic neoplasm.