FASN and cancer: Indeed, recent studies have obtained similar results, showing that the transcription of FASN is enhanced by activation of phosphatidylinositol 3-kinase (PI3-K) and mitogen-activated protein (MAP) kinase pathways through the key transcriptional factor sterol regulatory element-binding protein 1 (SREBP-1) and SREBP-2 in several cancer cells [18], [65] as well as in HepG2 cells.