In a tsetse fly-mediated T. brucei infection model that mimics the natural route of infection, Mif deficiency did not affect parasitemia development but resulted in a prolonged survival (Fig. S2A-B) and a reduced pro-inflammatory cytokine profile (mainly IFN-γ) together with an increased IL-10 production during the chronic stage of infection (Fig. S2C). The gene discussed is IL10; the disease is infection.