Further qRT-PCR analysis of pro-angiogenic gene expression was consistent with the above observation, that a higher level of VEGF-A and angiopoietin-1 (Ang-1) expression were observed in livers transplanted with HD cultured cells, accompanied with an increased expression of VEGF receptor-2 (VEGFR-2) but decreased expression of Tie-2 (Fig. 7B). The gene discussed is ANGPT1; the disease is Huntington disease.