In addition, multiple genes at the 5′ and 3′ ends of the Protocadherin B cluster were downregulated (not shown), while Stag1 (which encodes a cohesin subunit) was upregulated; both of these changes are hallmarks of Nipbl deficiency in other tissues [3]. This evidence concerns the gene STAG1 and hyperinsulinemic hypoglycemia, familial, 4.