In up-regulated genes of head kidney samples, 2 genes respond to infection by D. pseudospathaceum-clone I (HYAL2, PRF1), 3 to clone XII (RGCC, CYP27B1, CCR9) and 6 to the clone mix treatment (ITGA5, SIX1, ATP1B3, MEF2C, MLF1, MYLPF). This evidence concerns the gene PRF1 and infection.