In total, 388 (32.7%) of the 1187 breast cancer cases showed high galectin-3 expression, although the expression level varied significantly with respect to age, tumor size, histological grade, tumor stage, lymph node metastasis, and TNC (P = 0.023, 0.000, 0.000, 0.023, 0.001, and 0.000, respectively; Table 1). This evidence concerns the gene LGALS3 and breast cancer.