PDK1 and neoplasm: Denko et al. reported that dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase inhibitor 1 (PDK1) that phosphorylates and inhibits pyruvate dehydrogenase from using pyruvate to fuel the mitochondrial TCA cycle, transiently increases cellular oxygen consumption and enhances tumor response to hypoxic cytotoxin PR-104 [35].