MYD88 and infection: To obtain insight in the cause of early lethality of LysM-Myd88−/− and Tie2-Myd88−/− mice we next infected mice with Klebsiella in a separate experiment and harvested lungs, blood, spleen and liver for quantitative cultures 24 hours post infection (i.e. shortly before the first deaths were expected to occur), seeking to collect data representative for host defense at the primary site of infection and bacterial dissemination.