Since TLRs and other innate immune sensors are widely distributed among different cell types in the airways, comprising both hematopoietic and non-hematopoietic cells, our laboratory engaged in several studies seeking to dissect the cell-specific contribution of TLR and MyD88 signaling in host defense during Klebsiella pneumonia derived sepsis [12], [32]. Here, MYD88 is linked to Sepsis.