The serum myostatin level was significantly lower in those patients who had MetS (7.39±3.46 vs 9.49±4.35 ng/ml, p<0.001), impaired fasting glucose (7.94±3.80 vs 8.91±4.26 ng/ml, p = 0.020), higher BMI (7.61±3.84 vs 8.94±3.98 ng/ml, p = 0.002), larger abdominal girth (7.46±3.61 vs 9.39±4.23 ng/ml, p<0.001), lower HDL cholesterol (7.56±2.92 vs 9.07±4.45 ng/ml, p = 0.001), and higher TG (6.93±2.95 vs 8.85±4.23 ng/ml, p<0.001). The gene discussed is MSTN; the disease is metabolic syndrome.