CD40LG and parasitic infectious disease: In the case of the unimmunized control volunteers and ME-TRAP vaccinees (both groups being ‘blood-stage antigen naïve’), there was a significant positive correlation between their dC+35 IgG titers against MSP119 and time-to-diagnosis as well as parasitemia at diagnosis, thus suggesting the degree of parasite exposure strongly influences antibody induction against this antigen.