IGHG3 and malaria: In the context of natural malaria immunity, IgG1 and IgG3 responses against merozoite antigens or infected RBC, including IgG1 against MSP1 and IgG3 against AMA1 [75], [76], have been most often associated with clinical protection in immuno-epidemiological studies [75], [77], [78], with one report also associating IgG2 with protection [79].