FOXM1 and Familial prostate cancer: Foxm1 is activated by the Ras/Erk signaling pathway [9] and transcriptionally induces cell cycle-regulatory genes, including Cdc25b, Cyclin B1, Plk1, Aurora B. Recent studies demonstrated that Foxm1 is required for initiation and progression of various cancers, including prostate cancer [9]–[11].