RNF26 and viral infectious disease: Consistent with the gene induction experiments, we found that although SeV- or HSV-1-induced phosphorylation of TBK1 and IκBα was inhibited in THP-1-RNF26-RNAi cells, phosphorylation of IRF3 was inhibited at the early time points and increased at the late time points in THP-1-RNF26-RNAi stable cells compared to that in control cells after viral infection (Figure 6G).