After IL-22 was first described [39], extensive studies have shown that IL-22 has immunological effects, predominantly proinflammatory, in various diseases or models, such as bleomycin induced lung inflammation, and other disease models, including arthritis, hepatitis, psoriasis, atopic dermatitis, and inflammatory bowel disease [11], [40]–[45]. The gene discussed is IL22; the disease is inflammatory bowel disease.