To reveal the biological roles and molecular mechanisms of LOXL2 and its variants, we overexpressed wild-type LOXL2 (LOXL2-WT) and LOXL2-e13 in ESCC KYSE150 cell line and analyzed the mRNA profiles by the PrimeView Human Gene Expression Array (Affymetrix Corp., St Clara, CA, USA). The gene discussed is LOXL2; the disease is esophageal squamous cell carcinoma.