However, our data indicates that curcumin is a potent inhibitor of purified human RNase L at submicromolar levels, which might have important physiological consequences particularly for some types of chronic inflammation; it may possibly be used as therapeutic approach to treat RNase L abnormalities, for example, CFS, colorectal carcinogenesis, scrapie infection in brain, and other defects of the RNase L-pathway. Here, RNASEL is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.