CDKN1B and familial pancreatic carcinoma: DIM was also found to downregulate miR-221 and upregulates its targets: PTEN, cyclin-dependent kinase inhibitor 1B (p27kip1), cyclin-dependent kinase inhibitor 1C (p57kip2), and p53 up-regulated modulator of apoptosis (PUMA), leading to suppression of cell proliferation and migration of MiaPaCa-2 and Panc-1 pancreatic cancer cells.