IRAK1 and familial pancreatic carcinoma: Treatment with DIM (which increased miR-146a expression) or reexpression of miR-146a downregulated EGFR, interleukin 1 receptor-associated kinase 1 (IRAK-1), NF-κB and metastasis-associated protein, member 2 (MTA2), blocking cell invasion in Colo357 and Panc-1 pancreatic cancer cells [60].