Known as tumor-associated macrophages (TAMs), they may sense hypoxia in tumor tissue and secrete VEGFs, basic fibroblast growth factor (bFGF), thymidine phosphorylase (TP), MMP-2, MPP-7, MPP-9 and MPP-12 [144], and urokinase type plasminogen activator (uPA) [145] to induce both hem- and lymphangiogenesis. This evidence concerns the gene MMP2 and neoplasm.