This meta-analysis identified six SNPs within or nearby FOXO1 (rs2721051), FNDC3B (rs4894535), RXRA-COL5A1 (rs1536482), MPDZ-NFIB (rs1324183), COL5A1 (rs7044529), and BANP-ZNF469 (rs9938149) genes/loci that were strongly associated with the risk of keratoconus. The gene discussed is ZNF469; the disease is keratoconus.