Considering: (1) the role of hnRNP A1 in cellular function; (2) variant forms of hnRNP A1 cause neurodegenerative disease, and (3) hnRNP A1 is an autoimmune target in MS patients, we hypothesized that MS patients would contain novel genomic DNA single nucleotide variants (SNVs) in hnRNP A1-M9, which when expressed, would alter cellular function and contribute to cell death. This evidence concerns the gene EIF3K and myeloid sarcoma.