Subsequent studies using several thousand MS cases and controls, which analyzed hundreds of thousands of autosomal SNPs, confirmed the association of MS with major MHC Class II HLA-DRB1 (DRB1 *15:01, *15:03, *13:03) and the protective effect MHC Class I HLA-A*021,8. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.