Treatment of acute lymphoblastic leukemia cell lines of CCRF-CEM and Jurkat with methotrexate, vinblastine or doxorubicin caused certain increase of ABCA2 expression in Jurkat cell line, and of ABCA3 in CCRE-CEM and Jurkat cell lines (38, 70). This evidence concerns the gene ABCA2 and acute lymphoblastic leukemia.