Among the genetic subtypes, Philadelphia (Ph) chromosome, which results from a reciprocal translocation between Abelson (ABL1) from chromosome 9 and breakpoint cluster region (BCR) from chromosome 22, is the most frequent cytogenetic aberration which is found in ~ 25% of adult ALL cases, and in more than 50% of patients, aged 50 years or more [3,4]. This evidence concerns the gene ABL1 and acute lymphoblastic leukemia.