Comparison with gene expression profiling shows that enhanced expression andfunction of the MYC oncoprotein, a downstream effector of both WNT- and RAS-dependent signaltransduction, is a common denominator of a vast majority of colon tumors (CancerGenomeAtlasNetwork,2012; van de Wetering et al, 2002). The gene discussed is MYC; the disease is colonic neoplasm.