The notion that HUWE1 antagonizes assembly of MYC/MIZ1 repressive complexes is consistent withgenetic data showing that deletion of HUWE1 enhances MYC/MIZ1-dependent repression during skincarcinogenesis (Inoue et al, 2013).Importantly, MIZ1-dependent repression of Cdkn1a (encoding p21CIP1) expression is acritical function of MYC in Ras-driven skin tumorigenesis, since deletion ofMYC or MIZ1 inhibits Ras-induced tumor formationand upregulates p21CIP1 expression; tumor formation in the absence of MYC or MIZ1 is restored whenCdkn1a is co-deleted (Honnemann et al, 2012; Oskarsson et al, 2006). This evidence concerns the gene HUWE1 and neoplasm.