Asecond factor contributing to this specificity is the ARF tumor suppressor protein that is expressedin tumor but not in normal cells; ARF inhibits HUWE1, promotes the assembly of MYC/MIZ1 complexes,and inhibits transactivation by MYC (Chen et al, 2005; Herkert et al, 2010; Qi et al, 2004).Additionally, expression of HDAC2 is high in colon carcinoma cells since it is downstream of the WNTpathway (Zhu et al, 2004). Here, HUWE1 is linked to colon carcinoma.