HUWE1 and neoplasm: In human and mouse tumor cells, MYC binds to target promoters either as part of a binaryactivating complex with a partner protein, MAX, or as a ternary repressive complex that contains inaddition the zinc finger protein MIZ1; the balance of both complexes at each promoter determines thetranscriptional response to MYC (Eilers & Eisenman, 2008; Walz et al, 2014).HUWE1 associates with MYC, the related N-MYC protein, and with MIZ1 and ubiquitinates all threeproteins (Adhikary et al, 2005; Liet al, 2008; Yanget al, 2010).