Thus, ten ALS-associated genes SOD1 (position 9), FUS (position 34), ANG (position 19), TARDBP (position 1), ALS2 (position 4), VAPB (position 29), OPTN (position 190), VCP (position 46), MAPT (position 32), C9ORF72 (position 126) were prioritized among the top 1%, while an additional four genes (SETX (position 816), FIG 4 (position 1024), DAO (position 1441), SPG11 (position 1085) were among the top 7.5%. This evidence concerns the gene SPG11 and amyotrophic lateral sclerosis.