Among the TFs ranked at the top of the list of increased connectivity, our analysis identified colorectal cancer related genes: two oncogenes (MAFB[39] and GLI2[40]), proliferation-related genes (NOTCH3[41] and TGFB1[42]), epithelial-mesenchymal transition (SNAI2[43]) and the Wnt signaling genes SFRP4, TWIST1, SMARCA4 and DKK3, potentially involved in colorectal cancer angiogenesis [44]. The gene discussed is NOTCH3; the disease is colorectal cancer.