Our observations now describe a novel role for LAcmvIL-10 in the manipulation of cellular hsa-miR-92a, part of the 17-92 miRNA cluster, during latent HCMV infection, which in part explains the ability of HCMV to modulate the latency-associated expression of two important secreted cellular proteins, cIL-10 and CCL8 (16). This evidence concerns the gene CCL8 and cytomegalovirus infection.