CDKN1A and ovarian carcinoma: In ovarian cancer cells, we also reported that mifepristone promoted the upregulation of p21cip1 and p27kip1 and their association with Cdk2 in the nuclear compartment, thus blunting the activity of Cdk2 otherwise required to drive G1/S cell cycle progression (Goyeneche et al. 2007, 2012).