Membrane PRs have been shown in human breast biopsies, in cognate PR-positive MCF-7 and SKBR3 breast cancer cell lines, in cognate PR-negative MDA-MB-468 breast cancer cells, in HeLa cervical cancer cells, and in ovarian cancer biopsies (reviewed in Dressing et al. (2011)). The gene discussed is PGR; the disease is ovarian cancer.