Furthermore, lung and axillary metastases caused by the MPA-induced tumor line termed C7-2-HI, which expresses high levels of PR and ER, underwent complete regression when the animals received estrogens in combination with mifepristone; a reduction in metastatic growth was associated with increased expression of p21cip1 and p27kip1 (Vanzulli et al. 2005). This evidence concerns the gene CDKN1A and neoplasm.